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1. (WO2013123745) AZIDOTHYMIDINE QUINOLINE CONJUGATED COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN ANTI-HEPATOMA THERAPY

Pub. No.:    WO/2013/123745    International Application No.:    PCT/CN2012/077030
Publication Date: Fri Aug 30 01:59:59 CEST 2013 International Filing Date: Sat Jun 16 01:59:59 CEST 2012
IPC: C07H 19/06
C07H 1/00
A61K 31/7072
A61P 1/16
A61P 35/04
Applicants: HUA ZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
华中科技大学
ZHOU, Qibing
周琦冰
Inventors: ZHOU, Qibing
周琦冰
Title: AZIDOTHYMIDINE QUINOLINE CONJUGATED COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN ANTI-HEPATOMA THERAPY
Abstract:
The present invention provides an azidothymidine quinoline conjugated compound N-((l-(2-(hydroxymethyl)-5-(5-methyl-2, 4-dioxo-3, 4-dihydro-pyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl)-1H-1, 2, 3-triazol-4-yl) methyl)-6-(4b, 8, 8-trimethyl-4b, 5, 6, 7, 8, 8a, 9, 10-hexahydrodibenzo [a, c] phenazin-2-yloxy) hexanamide. The compound can be used for preparing anti-hepatoma drugs.