Search International and National Patent Collections

1. (WO2013123595) FORMULATION OF DOXYLAMINE AND PYRIDOXINE AND/OR METABOLITES OR SALTS THEREOF

Pub. No.:    WO/2013/123595    International Application No.:    PCT/CA2013/050125
Publication Date: Fri Aug 30 01:59:59 CEST 2013 International Filing Date: Tue Feb 19 00:59:59 CET 2013
IPC: A61K 9/00
A61K 31/415
A61K 31/4402
A61K 9/16
A61P 1/08
Applicants: DUCHESNAY INC.
Inventors: VRANDERICK, Manon
ST-ONGE, Jean-Luc
GEDEON, Christelle
GALLO, Michele
GERVAIS, Éric
Title: FORMULATION OF DOXYLAMINE AND PYRIDOXINE AND/OR METABOLITES OR SALTS THEREOF
Abstract:
A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).