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1. (WO2013123569) FORMULATION OF DOXYLAMINE AND PYRIDOXINE AND/OR METABOLITES OR SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/123569 International Application No.: PCT/CA2012/050103
Publication Date: 29.08.2013 International Filing Date: 22.02.2012
IPC:
A61K 31/4415 (2006.01) ,A61K 31/44 (2006.01) ,A61K 31/4402 (2006.01) ,A61K 31/675 (2006.01) ,A61K 9/00 (2006.01) ,A61P 1/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4415
Pyridoxine, i.e.vitamin B6
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4402
only substituted in position 2, e.g. pheniramine, bisacodyl
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
08
for nausea, cinetosis or vertigo; Antiemetics
Applicants: VRANDERICK, Manon[CA/CA]; CA (UsOnly)
ST-ONGE, Jean-Luc[CA/CA]; CA (UsOnly)
GEDEON, Christelle[CA/CA]; CA (UsOnly)
GALLO, Michele[CA/CA]; CA (UsOnly)
GERVAIS, Éric[CA/CA]; CA (UsOnly)
DUCHESNAY INC.[CA/CA]; 950, boul. Michèle-Bohec Blainville, Québec J7C 5E2, CA (AllExceptUS)
Inventors: VRANDERICK, Manon; CA
ST-ONGE, Jean-Luc; CA
GEDEON, Christelle; CA
GALLO, Michele; CA
GERVAIS, Éric; CA
Agent: GOUDREAU GAGE DUBUC; 2000 McGill College Suite 2200 Montréal, Québec H3A 3H3, CA
Priority Data:
Title (EN) FORMULATION OF DOXYLAMINE AND PYRIDOXINE AND/OR METABOLITES OR SALTS THEREOF
(FR) FORMULATION À BASE DE DOXYLAMINE ET DE PYRIDOXINE ET/OU DE MÉTABOLITES OU DE SELS ASSOCIÉS
Abstract:
(EN) A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).
(FR) L'invention concerne un système de dosage/forme posologique orale à double libération comprenant un composant/composition à libération immédiate et un composant/composition à libération retardée. Chacun des composants/compositions à libération immédiate et des composants/compositions à libération retardée comprend un ou plusieurs des éléments suivants: doxylamine, un analogique associé, un dérivé associé, un promédicament associé, un métabolite associé et/ou un sel associé et un ou plusieurs des éléments suivants: pyridoxine, un sel associé, un métabolite associé et/ou un sel du métabolite. Le système de dosage /forme posologique orale à libération double présente un profil pharmacocinétique amélioré par rapport à la formulation actuelle de Diclectin ® et est utile par exemple pour soulager les symptômes de nausée et de vomissements pendant la grossesse (NVP).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)