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1. (WO2013123569) FORMULATION OF DOXYLAMINE AND PYRIDOXINE AND/OR METABOLITES OR SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/123569    International Application No.:    PCT/CA2012/050103
Publication Date: 29.08.2013 International Filing Date: 22.02.2012
IPC:
A61K 31/4415 (2006.01), A61K 31/44 (2006.01), A61K 31/4402 (2006.01), A61K 31/675 (2006.01), A61K 9/00 (2006.01), A61P 1/08 (2006.01)
Applicants: DUCHESNAY INC. [CA/CA]; 950, boul. Michèle-Bohec Blainville, Québec J7C 5E2 (CA) (For All Designated States Except US).
VRANDERICK, Manon [CA/CA]; (CA) (For US Only).
ST-ONGE, Jean-Luc [CA/CA]; (CA) (For US Only).
GEDEON, Christelle [CA/CA]; (CA) (For US Only).
GALLO, Michele [CA/CA]; (CA) (For US Only).
GERVAIS, Éric [CA/CA]; (CA) (For US Only)
Inventors: VRANDERICK, Manon; (CA).
ST-ONGE, Jean-Luc; (CA).
GEDEON, Christelle; (CA).
GALLO, Michele; (CA).
GERVAIS, Éric; (CA)
Agent: GOUDREAU GAGE DUBUC; 2000 McGill College Suite 2200 Montréal, Québec H3A 3H3 (CA)
Priority Data:
Title (EN) FORMULATION OF DOXYLAMINE AND PYRIDOXINE AND/OR METABOLITES OR SALTS THEREOF
(FR) FORMULATION À BASE DE DOXYLAMINE ET DE PYRIDOXINE ET/OU DE MÉTABOLITES OU DE SELS ASSOCIÉS
Abstract: front page image
(EN)A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).
(FR)L'invention concerne un système de dosage/forme posologique orale à double libération comprenant un composant/composition à libération immédiate et un composant/composition à libération retardée. Chacun des composants/compositions à libération immédiate et des composants/compositions à libération retardée comprend un ou plusieurs des éléments suivants: doxylamine, un analogique associé, un dérivé associé, un promédicament associé, un métabolite associé et/ou un sel associé et un ou plusieurs des éléments suivants: pyridoxine, un sel associé, un métabolite associé et/ou un sel du métabolite. Le système de dosage /forme posologique orale à libération double présente un profil pharmacocinétique amélioré par rapport à la formulation actuelle de Diclectin ® et est utile par exemple pour soulager les symptômes de nausée et de vomissements pendant la grossesse (NVP).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)