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1. (WO2013123305) MODULATORS OF ACYL-COA LYSOCARDIOLIPIN ACYLTRANSFERASE 1 ( ALCAT1) AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/123305 International Application No.: PCT/US2013/026311
Publication Date: 22.08.2013 International Filing Date: 15.02.2013
IPC:
A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
THE PENN STATE RESEARCH FOUNDATION [US/US]; 304 Old Main University Park, PA 16802, US
Inventors:
SHI, Yuguang; US
Agent:
SLAVIN, Michael A.; McHale & Slavin, P.A. 2855 PGA Boulevard Palm Beach Gardens, FL 33410, US
Priority Data:
61/599,49616.02.2012US
Title (EN) MODULATORS OF ACYL-COA LYSOCARDIOLIPIN ACYLTRANSFERASE 1 ( ALCAT1) AND USES THEREOF
(FR) MODULATEURS DE L'ACYL-COA LYSOCARDIOLIPINE ACYLTRANSFÉRASE 1 (ALCAT1) ET LEURS UTILISATIONS
Abstract:
(EN) Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCATl ) expression, function or activity are provided. In particular, inhibitors of ALCATl are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCATl modulators are provided.
(FR) L'invention concerne des compositions de modulateurs de l'expression, de la fonction ou de l'activité de l'acyl-CoA lysocardiolipine acyltransférase 1 (ALCAT1). En particulier, les inhibiteurs d'ALCAT1 sont utiles dans le traitement de maladies métaboliques, de maladies cardiaques et de maladies en général associées au dysfonctionnement mitochondrial. L'invention concerne des dosages pour l'identification de nouveaux modulateurs d'ALCAT1.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)