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1. (WO2013123240) METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF OREXIN-2 RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2013/123240 International Application No.: PCT/US2013/026204
Publication Date: 22.08.2013 International Filing Date: 14.02.2013
IPC:
C07C 29/147 (2006.01) ,C07C 303/28 (2006.01) ,C07D 239/28 (2006.01) ,C12P 41/00 (2006.01) ,C07C 33/50 (2006.01) ,C07C 309/70 (2006.01) ,C07D 239/34 (2006.01) ,C07D 401/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
29
Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
132
by reduction of an oxygen-containing functional group
136
of CO containing groups, e.g. -COOH
147
of carboxylic acids or derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
303
Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
26
of esters of sulfonic acids
28
by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41
Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
33
Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
40
Halogenated unsaturated alcohols
50
containing six-membered aromatic rings and other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
309
Sulfonic acids; Halides, esters, or anhydrides thereof
63
Esters of sulfonic acids
64
having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
70
of a carbon skeleton substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
34
One oxygen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
EISAI R&D MANAGEMENT CO., LTD [JP/JP]; 6-10 Koishikawa 4-Chome Bunkyo-ku Tokyo, 112-8088, JP
MONIZ, George, Anthony [US/US]; US (US)
WILCOXEN, Annie, Zhu [US/US]; US (US)
BENAYOUD, Farid [US/US]; US (US)
LEE, Jaemoon [KR/US]; US (US)
ZHANG, Huiming [CN/US]; US (US)
TERAUCHI, Taro [JP/JP]; JP (US)
TAKEMURA, Ayumi [JP/JP]; JP (US)
YOSHIDA, Yu [JP/JP]; JP (US)
TANAKA, Toshiaki [JP/JP]; JP (US)
SORIMACHI, Keiichi [JP/JP]; JP (US)
NAOE, Yoshimitsu [JP/JP]; JP (US)
KAZUTA, Yuji [JP/JP]; JP (US)
Inventors:
MONIZ, George, Anthony; US
WILCOXEN, Annie, Zhu; US
BENAYOUD, Farid; US
LEE, Jaemoon; US
ZHANG, Huiming; US
TERAUCHI, Taro; JP
TAKEMURA, Ayumi; JP
YOSHIDA, Yu; JP
TANAKA, Toshiaki; JP
SORIMACHI, Keiichi; JP
NAOE, Yoshimitsu; JP
KAZUTA, Yuji; JP
Agent:
MYERS BIGEL SIBLEY & SAJOVEC, P.A.; P.O. Box 37428 Raleigh, NC 27627, US
Priority Data:
61/600,10917.02.2012US
Title (EN) METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF OREXIN-2 RECEPTOR ANTAGONISTS
(FR) PROCÉDÉS ET COMPOSÉS UTILES DANS LA SYNTHÈSE D'ANTAGONISTES DU RÉCEPTEUR 2 DE L'OREXINE
Abstract:
(EN) The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
(FR) La présente invention concerne des composés et des procédés qui sont utiles pour la préparation de composés utiles en tant qu'antagonistes du récepteur 2 de l'orexine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2861493CN104114524EP2814798US20150025237IL232949JP2015509939
SG11201403216URU2014137470RU0002617696BR112014019909IN6804/CHENP/2014