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Machine translation
1. (WO2013123087) PROCESS FOR MAKING RECOMBINANT ANTIDOTE TO FACTOR XA INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/123087    International Application No.:    PCT/US2013/025985
Publication Date: 22.08.2013 International Filing Date: 13.02.2013
IPC:
C12N 9/50 (2006.01), C12N 9/64 (2006.01)
Applicants: PORTOLA PHARMACEUTICALS, INC. [US/US]; 270 E. Grand Avenue, Suite 22 South San Francisco, California 94080 (US)
Inventors: LU, Genmin; (US).
CONLEY, Pamela B.; (US).
SINHA, Uma; (US)
Agent: TANNER, Lorna L.; SHEPPARD MULLIN RICHTER & HAMPTON LLP 379 Lytton Avenue Palo Alto, CA 94301-1479 (US)
Priority Data:
61/598,694 14.02.2012 US
Title (EN) PROCESS FOR MAKING RECOMBINANT ANTIDOTE TO FACTOR XA INHIBITOR
(FR) PROCÉDÉ DE FABRICATION D'ANTIDOTE RECOMBINANT À INHIBITEUR DU FACTEUR XA
Abstract: front page image
(EN)Disclosed are methods and isolated cells useful for the improved production of function fXa derivative protein that acts as a fXa inhibitor antidote. One aspect relates to an isolated cell comprising the r-Antidote polynucleotide and Furin polynucleotide. Another aspect relates to a method for preparing the cleaved two-chain r-Antidote by expressing, in a cell, the pre-processed r-Antidote polypeptide and a Furin polypeptide.
(FR)L'invention concerne des procédés et des cellules isolés, utiles pour la production améliorée d'une protéine issue de fXa fonctionnelle qui agit comme antidote à l'inhibiteur de fXa. Un aspect concerne une cellule isolée qui comporte le polynucléotide r-Antidote et le polynucléotide Furine. Un autre aspect concerne un procédé de préparation du r-Antidote à deux chaînes, clivé, par l'expression, dans une cellule, du polypeptide r‑Antidote prétraité et d'un polypeptide Furine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)