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1. (WO2013122321) USE OF HDAC6 AS HEPATOMA DIAGNOSIS MARKER AND THERAPEUTIC AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/122321    International Application No.:    PCT/KR2012/011549
Publication Date: 22.08.2013 International Filing Date: 27.12.2012
IPC:
G01N 33/68 (2006.01), C12Q 1/68 (2006.01), C12N 15/11 (2006.01), G01N 33/53 (2006.01)
Applicants: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 137-701 (KR)
Inventors: NAM, Suk Woo; (KR).
JUNG, Kwang Hwa; (KR)
Agent: LEE, Moon-Sup; Suite 301 Chungdong Building 1659-2 Inhundong, Gwanak-gu, Seoul 151-832 (KR)
Priority Data:
10-2012-0014893 14.02.2012 KR
Title (EN) USE OF HDAC6 AS HEPATOMA DIAGNOSIS MARKER AND THERAPEUTIC AGENT
(FR) UTILISATION DE HDAC6 EN TANT QUE MARQUEUR D'HÉPATOME ET AGENT THÉRAPEUTIQUE
(KO) HDAC6의 간암 진단용 마커 및 치료제로서의 용도
Abstract: front page image
(EN)The present invention relates to the use of HDAC6 (histone deacetylase 6) as a hepatoma diagnosis marker. More specifically, the present invention relates to a hepatoma diagnosis marker using HDAC6 gene or protein, a hepatoma diagnosis kit using same, and a hepatoma diagnosis method using same, and also relates to a method of screening for a substance able to prevent or cure hepatoma by recovering the expression of HDAC6 gene, and to a hepatoma preventing or treating composition comprising the substance. The HDAC6 gene according to the present invention has been confirmed to reduce the amount of expression in hepatoma tissue or cells compared to non-hepatoma tissue or cells. Therefore, employing HDAC6 gene as a hepatoma diagnosis marker makes it possible to rapidly and correctly diagnose hepatoma at an early stage, and, further, the invention may be used as a therapeutic agent for hepatoma.
(FR)La présente invention concerne l'utilisation de HDAC6 (histone désacétylase 6) en tant que marqueur de diagnostic de l'hépatome. Plus spécifiquement, la présente invention concerne un marqueur de diagnostic de l'hépatome à l'aide d'un gène ou une protéine HDAC6, un kit de diagnostic de l'hépatome l'utilisant, et un procédé de diagnostic de l'hépatome l'utilisant, et se rapporte également à un procédé de criblage pour une substance capable de prévenir ou guérir l'hépatome par la récupération de l'expression de gène HDAC6, et à une composition de prévention ou de traitement de l'hépatome comprenant la substance. Le gène HDAC6 selon la présente invention a été confirmé de façon à réduire la quantité de l'expression dans des tissus ou des cellules d'hépatome par rapport à des tissus ou des cellules non-hépatomes. Par conséquent, l'utilisation du gène HDAC6 en tant que marqueur de diagnostic de l'hépatome rend possible le diagnostic de façon rapide et correcte de l'hépatome à un stade précoce, et, en outre, l'invention peut être utilisée en tant qu'agent thérapeutique pour l' hépatome.
(KO)본 발명은 간암 진단용 마커로서의 HDAC6 (Histone deacetylase 6)의 용도에 관한 것이다. 보다 구체적으로, 본 발명은 HDAC6 유전자 또는 단백질을 이용한 간암 진단용 마커, 이를 이용한 간암 진단용 키트, 및 간암의 진단 방법에 관한 것이고, 또한 HDAC6 유전자의 발현을 회복시켜 간암을 예방 또는 치료할 수 있는 물질을 스크리닝하는 방법 및 상기 물질을 포함하는 간암의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 HDAC6 유전자는 비-간암의 조직 또는 세포에 비해 간암의 조직 또는 세포에서 발현양이 감소되는 것으로 확인됨에 따라 HDAC6 유전자를 간암 진단용 마커로 사용할 경우 간암을 조기에 신속하고 정확하게 진단 및 예측할 수 있는 효과가 있으며, 나아가 간암 치료제로 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)