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1. (WO2013122236) BASE-PROTECTED OLIGONUCLEOTIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/122236 International Application No.: PCT/JP2013/053769
Publication Date: 22.08.2013 International Filing Date: 15.02.2013
IPC:
C07H 19/073 (2006.01) ,C07H 21/04 (2006.01)
Applicants: AJINOMOTO CO., INC.[JP/JP]; 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315, JP
Inventors: HIRAI, Kunihiro; JP
KATAYAMA, Satoshi; JP
TORII, Takayoshi; JP
NAKAYA, Ryotaro; JP
TAKAHASHI, Daisuke; JP
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044, JP
Priority Data:
2012-03342917.02.2012JP
2012-25471820.11.2012JP
Title (EN) BASE-PROTECTED OLIGONUCLEOTIDE
(FR) OLIGONUCLÉOTIDE PROTÉGÉ PAR UNE BASE
(JA) 塩基部保護オリゴヌクレオチド
Abstract:
(EN) Provided is a protected nucleotide for elongation that makes it possible to realize a method for producing oligonucleotides by the phosphoramidite process that allows purification to be conducted by liquid-liquid extraction efficiently and at high yield. It was discovered that this can be achieved by using a specific base-protected oligonucleotide and/or a specific aromatic protected oligonucleotide containing a 3'-position branched chain.
(FR) Le nucléotide protégé pour l'allongement ci-décrit permet de mettre en œuvre un procédé de production d'oligonucléotides par la technique au phosphoramidite et de procéder à une purification efficace et à un rendement élevé par extraction liquide-liquide. On a découvert que ceci peut être obtenu en utilisant un oligonucléotide protégé par une base spécifique et/ou un oligonucléotide protégé par un aromatique spécifique contenant une chaîne ramifiée à la position 3'.
(JA)  効率的かつ高収率に、液-液抽出操作で精製可能な、ホスホロアミダイト法によるオリゴヌクレオチド製造方法を達成しうる、伸長用の保護ヌクレオチドを提供すること。 特定の塩基部保護オリゴヌクレオチド及び/又は特定の3'位分岐鎖含有芳香族保護オリゴヌクレオチドにより、上記課題が解決できることを見出した。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)