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1. (WO2013121429) FORMULATIONS AND KITS FOR FORMING BIOADHESIVE MATRICES

Pub. No.:    WO/2013/121429    International Application No.:    PCT/IL2013/050139
Publication Date: Fri Aug 23 01:59:59 CEST 2013 International Filing Date: Fri Feb 15 00:59:59 CET 2013
IPC: A61K 47/42
A61K 47/12
A61K 9/28
A61K 9/40
A61K 47/34
A61K 9/22
Applicants: TECHNOLOGY INNOVATION MOMENTUM FUND (ISRAEL) LIMITED PARTNERSHIP
Inventors: ZILBERMAN, Meital
SHEFY-PELEG, Adaya
COHEN, Binyamin
FOOX, Maytal
Title: FORMULATIONS AND KITS FOR FORMING BIOADHESIVE MATRICES
Abstract:
A bioadhesive formulation, comprising gelatin, alginate and a coupling agent, capable of forming a bioadhesive matrix, which is characterized by rapid curing, optimal viscosity, high bonding strength, flexibility, biocompatibility and biodegradability, is disclosed. Further disclosed is such a bioadhesive formulation which further comprises a bioactive agent, and a drug-eluting bioadhesive matrix formed therefrom, the bioadhesive matrix being capable of delivering the bioactive agent to a bodily site. Methods utilizing the bioadhesive formulations and matrices in various biological and medical procedures are also disclosed.