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1. (WO2013121034) METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING ADIPOSE TISSUE INFLAMMATION

Pub. No.:    WO/2013/121034    International Application No.:    PCT/EP2013/053148
Publication Date: Fri Aug 23 01:59:59 CEST 2013 International Filing Date: Tue Feb 19 00:59:59 CET 2013
IPC: C12N 15/113
A61K 31/7088
A61P 29/00
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
Inventors: VENTECLEF, Nicolas
CLEMENT, Karine
DALMAS, Elise
Title: METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING ADIPOSE TISSUE INFLAMMATION
Abstract:
The present invention relates to an inhibitor of interferon regulatory factor 5 (IRF5) activity or expression for use in a method for reducing adipose tissue inflammation in a subject. The present invention also relates to a method for screening a plurality of candidate compounds useful for reducing adipose tissue inflammation comprising the steps consisting of (a) testing each of the candidate compounds for its ability to inhibit interferon regulatory factor 5 activity or expression and (b) and positively selecting the candidate compounds capable of inhibiting said interferon regulatory factor 5 activity or expression.