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1. (WO2013120554) ANTIBODIES THAT BIND PEPTIDOGLYCAN RECOGNITION PROTEIN 1

Pub. No.:    WO/2013/120554    International Application No.:    PCT/EP2012/074093
Publication Date: Fri Aug 23 01:59:59 CEST 2013 International Filing Date: Sat Dec 01 00:59:59 CET 2012
IPC: C07K 16/18
A61K 39/395
Applicants: NOVO NORDISK A/S
Inventors: STENNICKE, Vibeke Westphal
READ, Christine Brender
KUIJPER, Joe
TANG, Xiaoting
HEIPEL, Mark
HJORTH, Siv Annegrethe
Title: ANTIBODIES THAT BIND PEPTIDOGLYCAN RECOGNITION PROTEIN 1
Abstract:
Disclosed herein is a method for identifying TREM-1 's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1 's ligand. Antibodies that reduce or block TREM-1 activation may be identified and selected using this method. Antibodies that bind to TREM-1 's ligand and reduce TREM-1 activity may be suitable for use as medicaments.