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1. (WO2013120466) A NEW SOLID FORM OF TAPENTADOL AND A METHOD OF ITS PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/120466 International Application No.: PCT/CZ2013/000016
Publication Date: 22.08.2013 International Filing Date: 18.02.2013
IPC:
A61K 31/135 (2006.01) ,C07C 215/62 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46
having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
56
with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
58
with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
62
the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Applicants:
ZENTIVA, K.S. [CZ/CZ]; U Kabelovny 130 102 37 Praha 10, CZ
Inventors:
VLASAKOVA, Ruzena; CZ
HAJICEK, Josef; CZ
RIDVAN, Ludek; CZ
MOHAMED, Sharmarke; GB
VERNER, Jiri; CZ
Agent:
JIROTKOVA, Ivana; ROTT, RUZICKA & GUTTMANN P.O. Box 44 120 00 Praha 2, CZ
Priority Data:
PV 2012-11517.02.2012CZ
Title (EN) A NEW SOLID FORM OF TAPENTADOL AND A METHOD OF ITS PREPARATION
(FR) NOUVELLE FORME SOLIDE DU TAPENTADOL ET PROCÉDÉ POUR SA PRÉPARATION
Abstract:
(EN) The present invention relates to a crystalline form of tapentadol hydrobromide of formula (i), chemically 3-[(1R,2R)-3-(dimethylamino)-l-ethyl-2-methylpropyl]phenol hydrobromide, which manifests the following characteristic reflection in an X-ray powder record using CuKa radiation: 14.6; 15.5; 17.9; 21.1; 21.8 ± 0.2° 2-theta, and a method of its preparation.
(FR) La présente invention porte sur une forme cristalline du bromhydrate de tapentadol de formule (I), chimiquement le bromhydrate de 3-[(1R,2R)-3-(diméthylamino)-1-éthyl-2-méthylpropyl]phénol, qui présente la réflexion caractéristique suivante, dans un enregistrement de diffraction des rayons X sur poudre utilisant la raie CuKα : des angles 2-thêta de 14,6 ; 15,5 ; 17,9 ; 21,1 ; 21,8 ± 0,2°, et sur un procédé pour sa préparation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)