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1. (WO2013120463) A METHOD FOR THE MANUFACTURE OF A POLYMORPHOUSLY STABLE PHARMACEUTICAL COMPOSITION CONTAINING AGOMELATINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/120463    International Application No.:    PCT/CZ2013/000012
Publication Date: 22.08.2013 International Filing Date: 11.02.2013
IPC:
A61K 9/14 (2006.01), A61K 9/20 (2006.01), A61K 31/165 (2006.01)
Applicants: ZENTIVA, K.S. [CZ/CZ]; U Kabelovny 130 102 37 Praha 10 (CZ)
Inventors: REZAC, Jaroslav; (CZ).
HANOVSKA, Anna; (CZ).
PRIBYL, Daniel; (CZ).
DAMMER, Ondrej; (CZ).
PROKOPOVA, Alena; (CZ)
Agent: JIROTKOVA, Ivana; ROTT, RUZICKA & GUTTMANN P.O. Box 44 120 00 Praha 2 (CZ)
Priority Data:
PV 2012-108 15.02.2012 CZ
Title (EN) A METHOD FOR THE MANUFACTURE OF A POLYMORPHOUSLY STABLE PHARMACEUTICAL COMPOSITION CONTAINING AGOMELATINE
(FR) PROCÉDÉ POUR LA FABRICATION D'UNE COMPOSITION PHARMACEUTIQUE À STABILITÉ POLYMORPHE CONTENANT DE L'AGOMÉLATINE
Abstract: front page image
(EN)The invention provides a thermodynamically stable solid solution of agomelatine, containing agomelatine dissolved in a polymeric carrier, which is polyvinylpyrrolidone and/or its copolymer, a method for the manufacture thereof and pharmaceutical compositions containing agomelatine (N-[2-(7-methoxy-1-naphtyl)ethyl]acetamide) of formula (I) and a method of their preparation.
(FR)L'invention porte sur une solution solide thermodynamiquement stable d'agomélatine, contenant de l'agomélatine dissoute dans un véhicule polymère, qui est la polyvinylpyrrolidone et/ou son copolymère, sur un procédé pour sa fabrication et sur des compositions pharmaceutiques contenant de l'agomélatine (du N-[2-(7-méthoxy-1-naphtyl)éthyl]acétamide) de formule (I) et sur un procédé pour leur préparation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)