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1. (WO2013120089) MOLECULAR DIAGNOSTIC SCREENING ASSAY

Pub. No.:    WO/2013/120089    International Application No.:    PCT/US2013/025608
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Tue Feb 12 00:59:59 CET 2013
IPC: G01N 33/53
C12Q 1/68
C07H 21/00
Applicants: RAINDANCE TECHNOLOGIES, INC.
Inventors: WATSON, Andrew
LINK, Darren, Roy
OLSON, Jeffrey, Charles
SAMUELS, Michael
Title: MOLECULAR DIAGNOSTIC SCREENING ASSAY
Abstract:
The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step.