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1. (WO2013120058) NOVEL SP-B & SP-C PEPTIDES, SYNTHETIC LUNG SURFACTANTS, AND USE THEREOF

Pub. No.:    WO/2013/120058    International Application No.:    PCT/US2013/025532
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Tue Feb 12 00:59:59 CET 2013
IPC: A61K 38/00
A61K 9/127
C07K 14/785
C07K 14/00
Applicants: UNIVERSITY OF ROCHESTER
LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR
Inventors: WALTHER, Frans, J.
GORDON, Larry, M.
WARING, Alan, J.
WANG, Zhengdong
NOTTER, Robert, H.
Title: NOVEL SP-B & SP-C PEPTIDES, SYNTHETIC LUNG SURFACTANTS, AND USE THEREOF
Abstract:
The present invention relates to synthetic lung surfactant compositions that include a novel surface active peptide and a phospholipid, including phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, naturally occurring phospholipids, or a combination thereof. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue and to deliver therapeutic agents are also disclosed.