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1. (WO2013119869) A MULTI-BIOMARKER-BASED OUTCOME RISK STRATIFICATION MODEL FOR ADULT SEPTIC SHOCK

Pub. No.:    WO/2013/119869    International Application No.:    PCT/US2013/025221
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Fri Feb 08 00:59:59 CET 2013
IPC: G01N 33/68
G01N 33/53
G01N 33/50
Applicants: CHILDREN'S HOSPITAL MEDICAL CENTER
Inventors: WONG, Hector R.
LINDSELL, Christopher John
Title: A MULTI-BIOMARKER-BASED OUTCOME RISK STRATIFICATION MODEL FOR ADULT SEPTIC SHOCK
Abstract:
Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in adult patients. In particular, the invention relates to identifying one or more biomarkers associated with septic shock in adult patients, obtaining a sample from an adult patient having at least one indication of septic shock, then quantifying from the sample an amount of one or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome. The invention further relates to diagnostic kits, tests, and/or arrays that can be used to quantify the one or more biomarkers associated with septic shock in adult patients.