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1. (WO2013119821) CLASS I AND II LANTIBIOTICS FROM GEOBACILLUS THERMODENITRIFICANS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/119821 International Application No.: PCT/US2013/025161
Publication Date: 15.08.2013 International Filing Date: 07.02.2013
IPC:
A61K 35/74 (2006.01) ,C12N 1/20 (2006.01) ,A61K 38/00 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS[US/US]; 352 Henry Administration Building, 506 South Wright Street Urbana, IL 61801, US
Inventors: VAN DER DONK, Wilfred, A.; US
GARG, Neha; US
GOTO, Yuki; JP
TANG, Weixin; US
Agent: HILLMAN, Lisa, M.W.; Mcdonnell Boehnen Hubert & Berghoff LLP 300 South Wacker Drive, Suite 3100 Chicago, IL 60606, US
Priority Data:
61/595,79007.02.2012US
Title (EN) CLASS I AND II LANTIBIOTICS FROM GEOBACILLUS THERMODENITRIFICANS
(FR) LANTIBIOTIQUES DE CLASSE I ET II ISSUS DE GEOBACILLUS THERMODENITRIFICANS
Abstract:
(EN) The disclosure provides lantibiotics geobacillin I and geobacillin II from Geobacillus thermodenitrificans, compositions comprising the lantibiotics and methods of use of the lantibiotics. Further disclosed are the sequences of lantibiotics geobacillin I and geobacillin II, and alternative structures of geobacillin I and geobacillin II comprising amino acid substitutions. Antimicrobial compositions comprising one or more isolated geobacillins and a pharmaceutically acceptable carrier, and methods of reducing reproduction of bacteria comprising administering to a subject a therapeutically effective amount of the antimicrobial composition are also provided.
(FR) La présente invention concerne des lantibiotiques géobacilline I et géobacilline II issus de Geobacillus thermodenitrificans, des compositions comprenant les lantibiotiques et des procédés d'utilisation des lantibiotiques. L'invention concerne en outre les séquences des lantibiotiques géobacilline I et géobacilline II, et d'autres structures de géobacilline I et géobacilline II comprenant des substitutions d'acides aminés. L'invention porte également sur des compositions antimicrobiennes comprenant un ou plusieurs géobacillines isolés et un excipient acceptable du point de vue pharmaceutique, des procédés de réduction de la reproduction des bactéries comprenant l'administration à un sujet d'une quantité efficace du point de vue thérapeutique de la composition antimicrobienne.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)