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1. (WO2013119809) BIOMARKERS FOR HEMATOLOGIC MALIGNACIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/119809    International Application No.:    PCT/US2013/025143
Publication Date: 15.08.2013 International Filing Date: 07.02.2013
IPC:
A61K 31/015 (2006.01), A61K 31/352 (2006.01), A61K 31/165 (2006.01), A61P 35/02 (2006.01), A01K 67/027 (2006.01), C12N 15/12 (2006.01)
Applicants: GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. [US/US]; 1120 15th Street, CJ-3301 Augusta, GA 30912 (US)
Inventors: SHE, Jin-Xiong; (US).
CHEN, Bo; (US)
Agent: PABST, Patrea, L.; Pabst Patent Group LLP 1545 Peachtree Street, N.E., Suite 320 Atlanta, GA 30309 (US)
Priority Data:
61/596,971 09.02.2012 US
Title (EN) BIOMARKERS FOR HEMATOLOGIC MALIGNACIES
(FR) BIOMARQUEURS POUR CANCERS HÉMATOLOGIQUES
Abstract: front page image
(EN)It has been discovered that STAT5 phosphorylation and CD 150 are effective biomarkers for detecting, diagnosing, and monitoring hematological malignancies, including for example lymphomas. Compositions and methods for identifying therapeutic agents for the treatment of hematologic malignancies using p-STAT5, CD150 or both as biomarkers are described.
(FR)On s'est aperçu que la phosphorylation de la protéine STAT5 et la protéine CD150 constituent des biomarqueurs efficaces de détection, de diagnostic et de suivi des cancers hématologiques, dont, par exemple, les lymphomes. L'invention concerne également des compositions et des méthodes permettant d'identifier des agents thérapeutiques utilisables en vue du traitement de cancers hématologiques et faisant appel à la protéine STAT5 phosphorylée et/ou à la protéine CD150 en tant que biomarqueur(s).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)