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1. (WO2013119705) METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING

Pub. No.:    WO/2013/119705    International Application No.:    PCT/US2013/024985
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Thu Feb 07 00:59:59 CET 2013
IPC: A61K 48/00
Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION
INTEGRATED DNA TECHNOLOGIES, INC.
Inventors: MCCRAY, Paul
RAMACHANDRAN, Shyam
XING, Yi
WELSH, Michael
BEHLKE, Mark
Title: METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING
Abstract:
The present invention relates to therapeutic agents comprising miR-138, a miR-138 mimic, a SIN3A RNAi molecule, an anti-SIN3A RNAi molecule, and/or an anti-SIN3A antisense oligonucleotide (ASO) or other agent that suppresses SIN3A expression, a small molecule drug that interferes with SIN3A activity or whose actions mimic the biological effects ofSIN3A suppression and methods of use ofthese therapeutic agents to treat cystic fibrosis.