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1. (WO2013119639) SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/119639    International Application No.:    PCT/US2013/024903
Publication Date: 15.08.2013 International Filing Date: 06.02.2013
IPC:
A61K 31/40 (2006.01), A61K 31/445 (2006.01)
Applicants: EOLAS THERAPEUTICS, INC. [US/US]; 7445 Trigo Lane Carlsbad, California 92009 (US)
Inventors: KAMENECKA, Theodore; (US).
JIANG, Rong; (US).
SONG, Xinyi; (US)
Agent: PERDOK SHONKA, Monique M.; Schwegman, Lundberg & Woessner, P.A. P.O. Box 2938 Minneapolis, Minnesota 55402 (US)
Priority Data:
61/596,062 07.02.2012 US
Title (EN) SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS
(FR) PIPÉRIDINES/PROLINES SUBSTITUÉES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE L'OREXINE
Abstract: front page image
(EN)The present invention is directed to compounds that can modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a compound of the invention; to methods of treatment of malconditions in patients wherein modulation of an orexin receptor is medically indicated; and to methods of preparation of compounds of the invention.
(FR)La présente invention concerne des composés qui peuvent moduler la bioactivité d'un récepteur de l'orexine, tel que OX1 ou OX2, ou les deux ; des compositions pharmaceutiques et des combinaisons comprenant un composé de l'invention ; des procédés de traitement d'états pathologiques de patients chez lesquels la modulation d'un récepteur de l'orexine est médicalement indiquée ; et des procédés de préparation de composés de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)