An electronic device with a protective circuit against damage by electrostatic discharge includes a discharge current path (channel MN1 ) connectable between an input (PAD) to be protected and a ground pin (VSS). An enabling circuit (C1, R2) outputs a control signal (16) for connecting the discharge current path in the event of an electrostatic discharge. A deactivating circuit (MN3, MP5, MN6) which deactivates the enabling circuit during operation of the electronic device is controlled by the inverted control signal. A method of protecting an electronic device against damage by electrostatic discharge includes providing a control signal for connecting a discharge current path between an input to be protected and a ground pin in the event of an electrostatic discharge. An inverted control signal is applied to the inverted control signal to a deactivating circuit. The inverted control signal prevents connection of the discharge current path between the input to be protected and ground during operation of the electronic device.