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1. (WO2013119193) EXTRACELLULAR MITOCHONDRIA-BASED SCREENING AND TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/119193    International Application No.:    PCT/US2011/057405
Publication Date: 15.08.2013 International Filing Date: 21.10.2011
IPC:
C12Q 1/68 (2006.01)
Applicants: TUFTS UNIVERSITY [US/US]; 136 Harrison Avenue Boston, MA 02111 (US) (For All Designated States Except US).
THEOHARIDES, Theoharis, C. [US/US]; (US) (For US Only).
ZHANG, Bodi [CN/US]; (US) (For US Only)
Inventors: THEOHARIDES, Theoharis, C.; (US).
ZHANG, Bodi; (US)
Agent: WU, Duan; Milstein, Zhang & Wu, Llc 2000 Commonwealth Ave., Ste. 400 Newton, MA 02466 (US)
Priority Data:
61/405,414 21.10.2010 US
Title (EN) EXTRACELLULAR MITOCHONDRIA-BASED SCREENING AND TREATMENT
(FR) DÉPISTAGE ET TRAITEMENT BASÉS SUR LES MITOCHONDRIES EXTRACELLULAIRES
Abstract: front page image
(EN)Based on novel findings that mitochondrial dynamics regulate mast cell secretion of pre-stored TNF stimulated by SP, novel methods and compositions related to extracellular mitochondrial DNA (mtDNA) are provided for the diagnosis and treatment of diseases brought on by malfunctioning immune activities, e.g., inflammatory, autoimmune diseases, and neurodegenerative diseases such as ASD.
(FR)La présente invention concerne, sur la base de nouvelles découvertes selon lesquelles les dynamiques mitochondriales régulent la sécrétion de mastocytes de TNF pré-stocké stimulé par la SP, de nouveaux procédés et de nouvelles compositions liés à l'ADN mitochondrial extracellulaire (ADNmt) pour le diagnostic et le traitement de maladies induites par un dysfonctionnement des activités immunitaires, par exemple, des maladies inflammatoires, auto-immunes, et neurodégénératives telles que les TSA.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)