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1. (WO2013118949) PHENYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS FOR PREVENTING, IMPROVING OR TREATING DISEASES RELATED TO VASCULAR ENDOTHELIAL CELLS OR DIABETES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/118949 International Application No.: PCT/KR2012/004805
Publication Date: 15.08.2013 International Filing Date: 18.06.2012
IPC:
C07C 43/205 (2006.01) ,C07C 39/04 (2006.01) ,A61K 31/05 (2006.01) ,A61P 3/10 (2006.01)
Applicants: KIM, Jin Sook[KR/KR]; KR (UsOnly)
KIM, Junghyun[KR/KR]; KR (UsOnly)
KIM, Chan-Sik[KR/KR]; KR (UsOnly)
KIM, Young Sook[KR/KR]; KR (UsOnly)
SHON, Eunjin[KR/KR]; KR (UsOnly)
JUNG, Dong Ho[KR/KR]; KR (UsOnly)
LEE, Yun Mi[KR/KR]; KR (UsOnly)
JUNG, Seung Hyun[KR/KR]; KR (UsOnly)
LEE, Yu-Ri[KR/KR]; KR (UsOnly)
KOREA INSTITUTE OF ORIENTAL MEDICINE[KR/KR]; 461-24 Jeonmin-dong Yuseoung-gu Daejeon 305-811, KR (AllExceptUS)
Inventors: KIM, Jin Sook; KR
KIM, Junghyun; KR
KIM, Chan-Sik; KR
KIM, Young Sook; KR
SHON, Eunjin; KR
JUNG, Dong Ho; KR
LEE, Yun Mi; KR
JUNG, Seung Hyun; KR
LEE, Yu-Ri; KR
Agent: LEE, Won Hee; 8th Fl. Sung-ji Heights II 642-16 Yoksam-dong Kangnam-ku Seoul 135-080, KR
Priority Data:
10-2012-001285408.02.2012KR
10-2012-006488218.06.2012KR
Title (EN) PHENYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS FOR PREVENTING, IMPROVING OR TREATING DISEASES RELATED TO VASCULAR ENDOTHELIAL CELLS OR DIABETES
(FR) DÉRIVÉS DE PHÉNYLE OU SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI, LEURS PROCÉDÉS DE PRÉPARATION, ET COMPOSITION LES COMPRENANT COMME PRINCIPES ACTIFS POUR PRÉVENIR, AMÉLIORER OU TRAITER DES MALADIES ASSOCIÉES AUX CELLULES ENDOTHÉLIALES VASCULAIRES OU LE DIABÈTE
(KO) 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 혈관내피세포 관련 질환 또는 당뇨병의 예방, 개선 또는 치료용 조성물
Abstract: front page image
(EN) The present invention relates to phenyl derivatives or to the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a composition comprising same as active ingredients for preventing, improving or treating diseases related to vascular endothelial cells such as diabetes and diabetic complications. The phenyl derivatives according to the present invention may effectively regulate glucose use, have excellent effects in inhibiting the production of advanced glycation end-product which is a causing factor in diabetic complications, have superior effects in treating (preventing) the pathological widening of the diameter of a vitreous body vessel by hyperglycemia in an animal model (zebra fish), prevent a destruction of a blood-retinal barrier in a diabetic retinopathy-induced animal model (SD rat), increase occludin, which is a protein constituting a tight junction, and significantly reduce pathologically-increased vascular endothelial growth factors. Therefore, the phenyl derivatives of the present invention may be effectively used as a composition for preventing, improving or treating diseases related to vascular endothelial cells, such as diabetes and diabetic complications.
(FR) La présente invention concerne des dérivés de phényle ou leurs sels pharmaceutiquement acceptables, un procédé pour leur préparation et une composition les comprenant comme principes actifs pour prévenir, améliorer ou traiter des maladies associées aux cellules endothéliales vasculaires telles que le diabète et les complications diabétiques. Les dérivés de phényle selon la présente invention peuvent réguler efficacement l'utilisation de glucose, ont d'excellents effets dans l'inhibition de la production de produit final de glycation avancée qui est un facteur causal dans les complications diabétiques, ont des effets supérieurs dans le traitement (la prévention) de l'élargissement pathologique du diamètre d'un récipient de corps vitré par hyperglycémie chez un modèle animal (poisson zèbre), préviennent une destruction d'une barrière hémato-rétinienne dans un modèle animal à rétinopathie diabétique induite (rat SD), augmentent l'occludine, qui est une protéine constituant une jonction serrée et réduisent significativement des facteurs de croissance de l'endothélium vasculaire augmentés pathologiquement. Par conséquent, les dérivés de phényle de la présente invention peuvent être utilisés efficacement comme composition pour prévenir, améliorer ou traiter des maladies associées aux cellules endothéliales vasculaires telles que le diabète et les complications diabétiques.
(KO) 【요약서】 본 발명은 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병, 당뇨합병증 등의 혈관내피세포 관련 질환의 예방, 개선 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 페닐 유도체는 포도당 이용율을 효과적으로 조절하고, 당뇨합병증의 원인 인자인 최종당화산물 생성 억제 효과가 뛰어나며, 동물모델(제브라피쉬)에서 고혈당으로 눈의 유리체 혈관 지름이 병리적으로 넓어지는 것을 치료(예방)하는 효과가 우수할 뿐만 아니라, 당뇨성 망막증이 유도된 동물모델(SD 래트)에서 혈관망막장벽의 파괴를 방지하고, 치밀이음새를 구성하는 단백질인 오클루딘은 증가시키며, 병리적으로 증가한 신생혈관성장인자를 유의적으로 감소시키는 효과를 나타내므로 당뇨병, 당뇨합병증 등의 혈관내피세포 관련 질환의 예방, 개선 또는 치료용 조성물로 유용하게 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)