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1. (WO2013118857) ANTISENSE OLIGONUCLEOTIDE FOR ACSL1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/118857    International Application No.:    PCT/JP2013/052997
Publication Date: 15.08.2013 International Filing Date: 08.02.2013
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01), A61P 43/00 (2006.01)
Applicants: OSAKA UNIVERSITY [JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871 (JP).
SHIONOGI & CO., LTD. [JP/JP]; 1-8, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP)
Inventors: OBIKA, Satoshi; (JP).
HORI, Shinichiro; (JP).
FUJIWARA, Takahiro; (JP).
KASUYA, Takeshi; (JP)
Agent: SAMEJIMA, Mutsumi; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001 (JP)
Priority Data:
2012-026989 10.02.2012 JP
Title (EN) ANTISENSE OLIGONUCLEOTIDE FOR ACSL1
(FR) OLIGONUCLÉOTIDE ANTISENS POUR ACSL1
(JA) ACSL1に対するアンチセンスオリゴヌクレオチド
Abstract: front page image
(EN)It is found that an antisense oligonucleotide comprising a sequence complementary to a sequence lying between position-95 and position-109, position-176 and position-192, position-467 and position-484, position-940 and position-954, position-1017 and position-1032, position-1102 and position-1116, position-1176 and position-1197, position-1222 and position-1236, position-1727 and position-1743, position-1858 and position-1873, position-1946 and position-1960, position-2294 and position-2308, position-2360 and position-2377, position-2449 and position-2469, position-2605 and position-2624, position-2689 and position-2703, position-2950 and position-2964, position-3424 and position-3438 or position-3591 and position-3605 in the sequence represented by SEQ ID NO: 2 has an excellent inhibitory activity on the expression of ACSL1. A pharmaceutical composition containing the antisense oligonucleotide for ACSL1 according to the present invention as an active ingredient is useful for the prevention or treatment of obesity or type-II diabetes.
(FR)L'invention concerne un oligonucléotide antisens comprenant une séquence complémentaire à une séquence s'étendant entre la position (95) et la position (109), la position (176) et la position (192), la position (467) et la position (484), la position (940) et la position (954), la position (1017) et la position (1032), la position (1102) et la position (1116), la position (1176) et la position (1197), la position (1222) et la position (1236), la position (1727) et la position (1743), la position (1858) et la position (1873), la position (1946) et la position (1960), la position (2294) et la position (2308), la position (2360) et la position (2377), la position (2449) et la position (2469), la position (2605) et la position (2624), la position (2689) et la position (2703), la position (2950) et la position (2964(, la position (3424( et la position (3438) ou la position (3591) et la position (3605) dans la séquence représentée par SEQ ID NO : 2 ayant une excellente activité inhibitrice de l'expression d'ACSL1. Une composition pharmaceutique contenant l'oligonucléotide antisens pour ACSL1 selon la présente invention en tant que principe actif est utile pour la prévention ou le traitement de l'obésité ou du diabète de type II.
(JA) 配列番号2の配列の95位~109位、176位~192位、467位~484位、940位~954位、1017位~1032位、1102位~1116位、1176位~1197位、1222位~1236位、1727位~1743位、1858位~1873位、1946位~1960位、2294位~2308位、2360位~2377位、2449位~2469位、2605位~2624位、2689位~2703位、2950位~2964位、3424位~3438位または3591位~3605位の配列に相補的な配列を含む、アンチセンスオリゴヌクレオチドが優れたACSL1発現抑制活性を有することを見出した。本発明のACSL1に対するアンチセンスオリゴヌクレオチドを有効成分として含む医薬組成物は、肥満症またはII型糖尿病の予防または治療に有用である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)