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Pub. No.:    WO/2013/118839    International Application No.:    PCT/JP2013/052939
Publication Date: 15.08.2013 International Filing Date: 07.02.2013
A61K 38/00 (2006.01), A61P 9/10 (2006.01), A61P 43/00 (2006.01)
Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER [JP/JP]; 5-7-1, Fujishirodai, Suita-shi, Osaka 5658565 (JP)
Inventors: SAWAMURA, Tatsuya; (JP).
KAKINO, Akemi; (JP)
Agent: HARAKENZO WORLD PATENT & TRADEMARK; Daiwa Minamimorimachi Building, 2-6, Tenjinbashi 2-chome Kita, Kita-ku, Osaka-shi, Osaka 5300041 (JP)
Priority Data:
2012-027793 10.02.2012 JP
(JA) 酸化LDL阻害剤
Abstract: front page image
(EN)The present invention provides an oxidized LDL inhibitor which (i) binds specifically to oxidized LDL, (ii) suppresses physiological activity of oxidized LDL, and (iii) is able to inhibit uptake of oxidized LDL into cells. This oxidized LDL inhibitor contains Del-1 protein as an active ingredient. The Del-1 protein comprises, for example, an amino acid sequence indicated by SEQ ID NO: 1.
(FR)Cette invention concerne un inhibiteur de LDL oxydées qui (i) se lie spécifiquement aux LDL oxydées, (ii) supprime l'activité physiologique des LDL oxydées, et (iii) est capable d'inhiber l'absorption des LDL oxydées dans les cellules. Cet inhibiteur de LDL oxydées contient la protéine Del-1 à titre de principe actif, ladite protéine Del-1 comprenant, par exemple, une séquence d'acides aminés représentée par SEQ ID No : 1.
(JA) 本発明は、(i)酸化LDLと特異的に結合し、(ii)酸化LDLの生理活性を抑制し、かつ(iii)酸化LDLの細胞内への取り込みを阻害し得る、酸化LDL阻害剤を提供する。本発明にかかる酸化LDL阻害剤は、Del-1タンパク質を有効成分として含有する。Del-1タンパク質は、例えば配列番号1に示されるアミノ酸配列からなる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)