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1. (WO2013118138) NOVEL PROCESS FOR THE PREPARATION OF RENIN INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/118138 International Application No.: PCT/IN2012/000815
Publication Date: 15.08.2013 International Filing Date: 12.12.2012
IPC:
C07D 275/06 (2006.01) ,C07C 41/22 (2006.01) ,C07C 41/26 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
275
Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings
04
condensed with carbocyclic rings or ring systems
06
with hetero atoms directly attached to the ring sulfur atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
41
Preparation of ethers; Preparation of compounds having groups, groups or groups
01
Preparation of ethers
18
by reactions not forming ether-oxygen bonds
22
by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
41
Preparation of ethers; Preparation of compounds having groups, groups or groups
01
Preparation of ethers
18
by reactions not forming ether-oxygen bonds
26
by introduction of hydroxy or O-metal groups
Applicants:
MYLAN LABORATORIES LTD [IN/IN]; IN (AllExceptUS)
RAMA, Shankar [IN/IN]; IN (US)
VADALI, Lakshmana Rao [IN/IN]; IN (US)
GORANTLA, Sarat Chandra Srikanth [IN/IN]; IN (US)
MANUKONDA, Seshadri rao [IN/IN]; IN (US)
POTLA, Venkata Srinivas Rao [IN/IN]; IN (US)
VADLAMUDI, Mohana Vamsi Krishna [IN/IN]; IN (US)
POTHANI, Jayaram [IN/IN]; IN (US)
ANUPATI, Raja Reddy [IN/IN]; IN (US)
Inventors:
MYLAN LABORATORIES LTD; IN
RAMA, Shankar; IN
VADALI, Lakshmana Rao; IN
GORANTLA, Sarat Chandra Srikanth; IN
MANUKONDA, Seshadri rao; IN
POTLA, Venkata Srinivas Rao; IN
VADLAMUDI, Mohana Vamsi Krishna; IN
POTHANI, Jayaram; IN
ANUPATI, Raja Reddy; IN
Agent:
NARAHARI BABU AMBATI; Plot No 34a, Anrich Industrial Estate Bollaram, Jinnaram Mandal, Medak Dist Hyderabad-500 055 Andhra Pradesh, IN
Priority Data:
4342/CHE/201113.12.2011IN
Title (EN) NOVEL PROCESS FOR THE PREPARATION OF RENIN INHIBITORS
(FR) NOUVEAU PROCÉDÉ DE PRÉPARATION D'INHIBITEURS DE RÉNINE
Abstract:
(EN) The present invention relates to an improved process for the preparation of compound of Formula-II, which is an intermediate in the preparation of Aliskiren and further conversion of compound of Formula-II into Aliskiren or its pharmaceutically acceptable salts. Formula-II wherein Ri and R2 are independently of one another H, Ci-C6 alkyl, C\- C6 halogenalkyl, C]-C6 alkoxy, Ci-C6 alkoxy-Ci-C6 alkyl, or Ci-C6 alkoxy-Ci- C6 alkyloxy and X is halogen selected from fluoro, chloro, bromo and iodo
(FR) La présente invention concerne un procédé amélioré pour la préparation du composé de Formule-II, qui est un intermédiaire dans la préparation d'Aliskirène et la conversion ultérieure du composé de Formule II en Aliskirène ou de ses sels pharmaceutiquement acceptables. Formule-II dans laquelle R1 et R2 représentent, indépendamment l'un de l'autre, H, C1-C6 alkyle, C1- C6 halogenalkyle, C1-C6 alcoxy, C1-C6 alcoxy-C1-C6 alkyle, ou C1-C6 alcoxy-C1- C6 alkyloxy et X représente halogène sélectionné parmi fluoro, chloro, bromo et iodo.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)