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1. (WO2013118130) A PROCESS FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE CARBOXAMIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/118130 International Application No.: PCT/IN2012/000086
Publication Date: 15.08.2013 International Filing Date: 06.02.2012
IPC:
C07D 413/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
Applicants:
MOHAN RAO, dodda [IN/IN]; IN (UsOnly)
VENKAT REDDY, buthukuri [IN/IN]; IN (UsOnly)
SYMED LABS LIMITED [IN/IN]; 8-3-166/6&7, II Floor, Sree Arcade, Erragadda, Andhra Pradesh Hyderabad 500018, IN (AllExceptUS)
Inventors:
MOHAN RAO, dodda; IN
VENKAT REDDY, buthukuri; IN
Priority Data:
Title (EN) A PROCESS FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE CARBOXAMIDE
(FR) PROCÉDÉ DE PRÉPARATION DE 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHÉNYL]-1,3-OXAZOLIDIN-5-YL}MÉTHYL)-2-THIOPHÈNE CARBOXAMIDE
Abstract:
(EN) The present invention relates to a process for the preparation of 5-chloro-N-( {(5S)-2-oxo-3-[ 4-(3-oxo-4-morpholinyl) phenyfj-l, 3-oxazolidin-5-yl} methyl)-2-thiophene-25 carboxamide (I). In an aspect, the present invention relates to a process for the preparation of 5-chloro-N({(5S)-2-oxc-3-[ 4-(3-oxo-4-morpholinyl) phenyl]: 1, 3-oxazolidin-5-yl} methyl)-2-thiophenecarboxamide of formula (I). Hence, there is a need to provide improved process for the preparation of rivaroxaban, which avoids the use of hazardous, expensive chemicals and also to avoid the formation of isomeric and other process related impurities while affording the compound desired yield and purity.
(FR) La présente invention concerne un procédé de préparation de 5-chloro-N-({ (5S)-2-oxo-3-[4-(3-oxo -4-morpholinyl) phényl]-1, 3-oxazolidin-5-yl} méthyl)-2-thiophène-carboxamide (I). Selon un aspect, la présente invention concerne un procédé de préparation de 5-chloro-N( {(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phényl] : 1, 3-oxazolidin-5-yl} méthyl)-2-thiophène-carboxamide de formule (I). Par conséquent, il est nécessaire de mettre en oeuvre un procédé amélioré pour la préparation de rivaroxaban, ce qui évite l'utilisation de produits chimiques dangereux et également la formation d'isomères et autres impuretés liées à ce procédé tout en pouvant obtenir le rendement et la pureté désirés pour ce composé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)