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1. (WO2013118109) METHODS AND APPARATUSES HARVESTING, MODIFYING AND REIMPLANTATION OF DERMAL MICRO -ORGANS

Pub. No.:    WO/2013/118109    International Application No.:    PCT/IL2012/050482
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Thu Nov 29 00:59:59 CET 2012
IPC: A61B 17/322
A61K 35/36
Applicants: MEDGENICS MEDICAL ISRAEL LTD.
Inventors: BELLOMO, Stephen, F.
OKUN, Alex
FUERST, Yaron
SHALHEVET, David
AMIR, Elisha
BUKHMAN, Mordechay
Title: METHODS AND APPARATUSES HARVESTING, MODIFYING AND REIMPLANTATION OF DERMAL MICRO -ORGANS
Abstract:
Embodiments of the present invention provide methods and apparatuses for harvesting Dermal Micro-organs (DMOs). Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro- architecture and three dimensional structure of the dermal tissue from which they are derived. An apparatus (5000, 6000) for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool (3014,6016) able to separate the DMO from the skin-related tissue structure. Exemplary embodiments of the invention provide a genetically modified dermal micro-organ expressing at least one recombinant gene product. Some embodiments of the invention provide methods and apparatuses for implanting a genetically modified DMO.