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1. (WO2013117713) REVERSAL OF SENESCENCE

Pub. No.:    WO/2013/117713    International Application No.:    PCT/EP2013/052579
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Sat Feb 09 00:59:59 CET 2013
IPC: C12N 15/113
A61K 31/713
A61P 43/00
A61Q 19/08
Applicants: QUEEN MARY & WESTFIELD COLLEGE, UNIVERSITY OF LONDON
Inventors: BISHOP, Cleo Lucinda
BEACH, David Hugh
Title: REVERSAL OF SENESCENCE
Abstract:
The present invention relates to the reversal of senescence, in particular the reversal of p16-mediated replicative senescence, using p16 inhibitors. The p16 inhibitors are generally small interfering RNA (siRNA) molecules that target and silence p16 expression, or anti-micro RNA molecules that target and disrupt senescence-associated micro RNA molecules. The use of such inhibitors in ex vivo cell culture methods, treatment of age-related disorders, cell culture media, reperfusion solutions, anti-ageing compositions, anti-wrinkle compositions and wound healing promoting compositions are also provided.