Search International and National Patent Collections

1. (WO2013117581) METABOLICALLY STABLE VARIANTS OF CHEMERIN 9

Pub. No.:    WO/2013/117581    International Application No.:    PCT/EP2013/052308
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Thu Feb 07 00:59:59 CET 2013
IPC: C07K 7/06
A61K 38/08
Applicants: CHARITE - UNIVERSITÄTSMEDIZIN BERLIN
Inventors: GROETZINGER, Carsten
BANDHOLTZ, Sebastian
WIEDENMANN, Bertram
Title: METABOLICALLY STABLE VARIANTS OF CHEMERIN 9
Abstract:
The invention relates to a chemerin-9 variant of the sequence Y1 F2 P3 G Q5 F6 A7 F8 S9, wherein a position is substituted, characterized by at least one of the following substitutions: - F2 is one of the group comprised of Y, W, J, V, M, an (S)-2-aminopropionic acid substituted at carbon 3 by a C4-, C5- or C6 linear alkyl or by a C5- or C6 circular alkyl moiety, or an (S)-2-amino-3-(nitrophenyl)-propionic acid; - Q5 is selected from the group comprised of M, T, S, Cit and Hnv; and/or - A7 is selected from the group comprised of T, S, H, G, C, and w, and to methods of diagnosis and therapy of oesophageal and pancreatic cancer, wherein the chemerin-9 variant of the invention is provided attached to a detectable label or therapeutically active agent.