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1. (WO2013117120) 2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2013/117120    International Application No.:    PCT/CN2013/070410
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Tue Jan 15 00:59:59 CET 2013
IPC: C07D 307/81
C07D 405/04
C07D 405/12
A61P 35/00
A61P 29/00
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
CISEN PHARMACEUTICAL CO., LTD.
辰欣药业股份有限公司
Inventors: YANG, Chunhao
杨春皓
MIAO, Zehong
缪泽鸿
DING, Jian
丁健
WANG, Meng
王猛
HE, Jinxue
贺金雪
TAN, Cun
谭村
CHEN, Yi
陈奕
Title: 2-ARYLBENZOFURAN-7-FORMAMIDE COMPOUNDS, PREPARATION METHOD AND USE THEREOF
Abstract:
Provided in the present invention are a 2-arylbenzofuran-7-formamide compound as shown in general formula I or a pharmacologically or physiologically acceptable salt thereof, a preparation method thereof and use thereof in preparing anti-tumour drugs, wherein R1 and R2 are each independently hydrogen, straight or branched chained C1-C4 alkyl, C3-C4 cycloalkyl or saturated 5- or 6-membered heterocyclyl containing oxygen or nitrogen; or R1 and R2 together with N form an unsubstituted or substituted saturated 5- or 6-membered heterocyclyl containing at least one heteroatom, wherein the heteroatom is O, N and S, the substituent is a methyl on N; R3 is a hydrogen atom or a chlorine atom; R4 is a hydrogen atom or a fluorine atom; X is CH, CF or N; and Y is CH, CF or N.