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1. (WO2013116948) INDOLIZINE DERIVATIVES

Pub. No.:    WO/2013/116948    International Application No.:    PCT/CA2013/050104
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Sat Feb 09 00:59:59 CET 2013
IPC: C07D 471/04
A61K 31/437
Applicants: PERAMPALLI NEKKAR, Praveen, Rao
NABIL KABIR, Saad
Inventors: PERAMPALLI NEKKAR, Praveen, Rao
NABIL KABIR, Saad
Title: INDOLIZINE DERIVATIVES
Abstract:
Disclosed herein are indolizine compounds of general formula I, wherein R1-R7, X and Y are as disclosed in the application, useful as inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2) and/or 15-lipoxygenase ( 15-LOX), as well as methods of preparation and use thereof, and compositions thereof Advantageously, certain compounds disclosed herein are capable of inhibiting both Lp-PLA2 and 15-LOX. Accordingly, provided herein are methods of inhibiting one or both of Lp-PLA2 and 15-LOX, and methods of treating diseases or conditions associated with Lp-PLA2 and/or 15-LOX.