Search International and National Patent Collections

1. (WO2013116903) METHODS FOR THE CHARACTERISATION OF INTERACTION SITES ON TARGET PROTEINS

Pub. No.:    WO/2013/116903    International Application No.:    PCT/AU2013/000110
Publication Date: Fri Aug 16 01:59:59 CEST 2013 International Filing Date: Fri Feb 08 00:59:59 CET 2013
IPC: C07K 14/195
A61K 38/16
C12Q 1/02
Applicants: PHYLOGICA LIMITED
CAMBRIDGE ENTERPRISE LIMITED
Inventors: WATT, Paul
HARDWICK, Bryn
McKENZIE, Grahame
VENKITARAMAN, Ashok
Title: METHODS FOR THE CHARACTERISATION OF INTERACTION SITES ON TARGET PROTEINS
Abstract:
The present invention relates to improved and integrated methods for the characterisation of an interaction site on a target protein that modulates the phenotype of a mammalian cell, such as a phenotype other than death and/or reduced growth. Such methods of the present invention include those to identify a target protein modulates such a phenotype of a mammalian cell, and optionally to characterise an interaction site on said target protein. Such identification and characterisation methods are useful in the development of research tools and/or therapeutics, such protein/peptide or small molecule therapeutics. Accordingly, the present invention also relates to methods of: identification of a ligand, such as a small molecule ligand, that binds to such a target protein; and identification a compound being a candidate modulator of said phenotype of a mammalian cell. The invention further relates to peptides or proteins, or fragments, variants and/or derivatives thereof) comprising certain amino acid sequences, nucleic acids encoding such peptides or proteins and uses of such peptides or proteins or of such nucleic acids.