Search International and National Patent Collections

1. (WO2013116786) CDK8/CDK19 SELECTIVE INHIBITORS AND THEIR USE IN ANTI-METASTATIC AND CHEMOPREVENTATIVE METHODS FOR CANCER

Pub. No.:    WO/2013/116786    International Application No.:    PCT/US2013/024515
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Sat Feb 02 00:59:59 CET 2013
IPC: A61K 31/517
C07D 239/94
A61P 35/00
Applicants: SENEX BIOTECHNOLOGY INC.
Inventors: ROBINSON, Igor, B.
PORTER, Donald, C.
WENTLAND, Mark, P.
Title: CDK8/CDK19 SELECTIVE INHIBITORS AND THEIR USE IN ANTI-METASTATIC AND CHEMOPREVENTATIVE METHODS FOR CANCER
Abstract:
The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI -related diseases. The invention provides new compounds having improved solubility and/or potency, and methods for their use. In various aspects, the invention relates to the treatment of cancer. The invention provides methods for chemoprevention and prevention of tumor recurrence or metastasis. The invention further provides diagnostic techniques for treatment for certain cancer types. The invention utilizes specific inhibitors of CDK8/19 and/or measurement of CDK8 levels in a patient.