Search International and National Patent Collections

1. (WO2013116690) ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE

Pub. No.:    WO/2013/116690    International Application No.:    PCT/US2013/024396
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Sat Feb 02 00:59:59 CET 2013
IPC: C07D 211/58
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: HAMMOCK, Bruce D.
LEE, Kin Sing
MORISSEAU, Christophe
Title: ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
Abstract:
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.