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1. WO2013116682 - MACROCYCLIC COMPOUNDS FOR MODULATING IL-17

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Publication Number WO/2013/116682
Publication Date 08.08.2013
International Application No. PCT/US2013/024386
International Filing Date 01.02.2013
IPC
C07D 255/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
255Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/-C07D253/178
02not condensed with other rings
C07D 257/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
C07D 273/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/-C07D271/183
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61K 31/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
CPC
A61K 31/366
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
A61K 31/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
42Oxazoles
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07D 255/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
255Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
02not condensed with other rings
C07D 257/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
C07D 257/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
10condensed with carbocyclic rings or ring systems
Applicants
  • ENSEMBLE THERAPEUTICS CORPORATION [US]/[US]
Inventors
  • TAYLOR, Michael
  • TERRETT, Nicholas, K.
  • CONNORS, William, H.
  • SHORTSLEEVES, Kelley, C.
  • SEIGAL, Benjamin, A.
  • SNEDEKER, Cheri
  • HALE, Stephen, P.
  • BRIGGS, Timothy, F.
  • FAVALORO, Frank, G.
  • CIPRIANI, Tyler, J.
  • YAN, Dingxue
  • ALEXANDER, Sethu, L.
  • THORARENSEN, Atli
  • XING, Li
Agents
  • DAVIS, Chad, E.
Priority Data
61/593,99302.02.2012US
61/725,87813.11.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MACROCYCLIC COMPOUNDS FOR MODULATING IL-17
(FR) COMPOSÉS MACROCYCLIQUES POUR UNE MODULATION D'IL-17
front page image
Abstract
(EN) The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.
(FR) L'invention concerne d'une manière générale des composés macrocycliques de formule I et leur utilisation thérapeutique. Plus particulièrement, l'invention concerne des composés macrocycliques qui modulent l'activité d'IL-17 et/ou sont utiles dans le traitement d'états médicaux, tels que des maladies inflammatoires et autres troubles associés à l'IL-17.
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Latest bibliographic data on file with the International Bureau
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