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1. (WO2013116455) IMPROVED SENSITIVITY AND SPECIFICITY FOR OVARIAN CANCER

Pub. No.:    WO/2013/116455    International Application No.:    PCT/US2013/024036
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Fri Feb 01 00:59:59 CET 2013
IPC: G01N 33/543
G01N 33/53
Applicants: BIO-RAD LABORATORIES, INC.
Inventors: BINDER, Steven R.
DELANOY, Michelle
ARJOMANDI, Audrey
FLANAGAN, John
Title: IMPROVED SENSITIVITY AND SPECIFICITY FOR OVARIAN CANCER
Abstract:
Solid phase immunoassay methods are presented for detecting the presence or absence of ovarian cancer biomarker CA-125 and secondary biomarkers IGFBP-2, prolactin, and osteopontin, and correlating the presence or absence or stage of ovarian cancer with the levels of these biomarkers. Detection of elevated levels of autoantibodies to said biomarkers is also presented as indicative of cancer.