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1. (WO2013116382) PURINONE COMPOUNDS AS KINASE INHIBITORS

Pub. No.:    WO/2013/116382    International Application No.:    PCT/US2013/023918
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Thu Jan 31 00:59:59 CET 2013
IPC: C07D 473/32
A61K 31/52
A61P 37/00
A61P 35/00
Applicants: PHARMACYCLICS, INC.
Inventors: CHEN, Wei
LOURY, David, J.
YAN, Shunqi
WANG, Longcheng
FRYE, Leah, Lynn
Title: PURINONE COMPOUNDS AS KINASE INHIBITORS
Abstract:
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.