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1. (WO2013115535) NOVEL CRYSTALLINE ACID ADDITION SALT OF TRICYCLO DERIVATIVE COMPOUND OR HYDRIDE THEREOF, AND PRODUCTION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/115535    International Application No.:    PCT/KR2013/000676
Publication Date: 08.08.2013 International Filing Date: 28.01.2013
IPC:
C07D 471/04 (2006.01), C07D 413/06 (2006.01), A61K 31/5377 (2006.01), A61P 25/00 (2006.01)
Applicants: JEIL PHARMACEUTICAL CO., LTD. [KR/KR]; 745-5 Banpo-Dong Seocho-ku Seoul 137-040 (KR)
Inventors: YE, In-Hae; (KR).
PARK, Chun-Ho; (KR).
CHOI, Jong-Hee; (KR).
KANG, Dong-il; (KR)
Agent: LEE, Won Hee; 8th Fl. Sung-ji Heights II 642-16 Yoksam-dong, Kangnam-ku Seoul 135-080 (KR)
Priority Data:
10-2012-0010465 01.02.2012 KR
Title (EN) NOVEL CRYSTALLINE ACID ADDITION SALT OF TRICYCLO DERIVATIVE COMPOUND OR HYDRIDE THEREOF, AND PRODUCTION METHOD THEREFOR
(FR) NOUVEAU SEL D'ADDITION D'ACIDE CRISTALLIN D'UN COMPOSÉ D'UN DÉRIVÉ TRICYCLO OU D'UN HYDRIDE DE CELUI-CI ET SON PROCÉDÉ DE PRODUCTION
(KO) 트리사이클로 유도체 화합물의 신규한 결정형 산부가염 또는 이의 수화물 및 이의 제조방법
Abstract: front page image
(EN)The present invention relates to a novel crystalline acid addition salt of a tricyclo derivative compound or a hydride thereof, and to a production method therefor. The crystalline acid addition salt or the hydride thereof according to the present invention is stable with respect to moisture and consequently stable with respect to hygroscopicity and so is very useful in maintaining quality when producing a drug, and, in addition, can be used to advantage as a pharmaceutical composition for treating neuropathic pain, epilepsy, stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, schizophrenia, chronic and acute pain, ischemic brain injury, neuronal loss after hypoxia, trauma and nerve damage, which are medical conditions induced by PARP (poly (ADP-ribose) polymerase) overactivity.
(FR)La présente invention concerne un nouveau sel d'addition d'acide cristallin d'un composé d'un dérivé tricyclo ou d'un hydride de celui-ci et son procédé de production. Le sel d'addition d'acide cristallin ou l'hydride de celui-ci selon la présente invention est stable à l'humidité et, par conséquent, stable à l'hygroscopie, et est ainsi très utile pour la maintien de la qualité lors de la production d'un médicament et, de plus, peut être utilisé de manière avantageuse comme composition pharmaceutique destinée au traitement de la douleur neuropathique, de l'épilepsie, d'une attaque, de la maladie d'Alzheimer, de la maladie de Parkinson, de la sclérose latérale amyotrophique (SLA), de la maladie de Huntington, de la schizophrénie, de la douleur chronique et aiguë, d'une lésion cérébrale ischémique, d'une perte neuronale suite à une hypoxie, d'une lésion traumatique et nerveuse, qui sont des affections médicales induites par la suractivité de la PARP (poly(ADP-ribose) polymérase).
(KO)본 발명은 트리사이클로 유도체 화합물의 신규한 결정형 산부가염 또는 이의 수화물 및 이의 제조방법에 관한 것이다. 본 발명에 의한 결정형 산부가염 또는 이의 수화물의 경우, 수분에 대하여 안정함에 따라 인습에 대하여 안정하므로 약물 제조시, 품질을 유지하는데 매우 유용하고, 뿐만 아니라, PARP(폴리(ADP-리보오스)폴리머라제) 과잉활성에 의해 유발되는 질환인 신경병리성 동통, 간질, 뇌졸중, 알츠하이머병, 파킨슨병, 근위축성 축삭 경화증(ALS), 헌팅턴병, 정신분열병, 만성 및 급성 통증, 허혈성 뇌손상, 저산소증 후의 신경세포 손실, 외상 및 신경 손상의 치료용 약학적 조성물로 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)