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1. (WO2013115486) NOVEL PIPERINE DERIVATIVE AND USE THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/115486    International Application No.:    PCT/KR2012/011548
Publication Date: 08.08.2013 International Filing Date: 27.12.2012
IPC:
C07D 317/46 (2006.01), C07D 405/12 (2006.01), A61K 31/36 (2006.01), A61P 3/00 (2006.01)
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR/KR]; 1FL., Yonsei Univ., Engineering Research Park 50 Yonsei-ro Seodaemun-gu Seoul 120-749 (KR)
Inventors: PARK, Tae Sun; (KR).
JEONG, Nak Shin; (KR)
Agent: LEE, Moon-Sup; Suite 301 Chungdong Building 1659-2 Inhundong Gwanak-gu Seoul 151-832 (KR)
Priority Data:
10-2012-0009362 31.01.2012 KR
Title (EN) NOVEL PIPERINE DERIVATIVE AND USE THEREFOR
(FR) NOUVEAU DÉRIVÉ DE PIPÉRINE ET APPLICATION ASSOCIÉE
(KO) 신규한 피페린 유도체 및 그의 용도
Abstract: front page image
(EN)The present invention relates to a novel piperine derivative. The present invention provides a pharmaceutical composition or functional food composition which comprises a piperine derivative as an active ingredient, and which is for preventing or treating a metabolic disorder selected from the group consisting of obesity, diabetes, dyslipidaemia, fatty liver and insulin resistance syndrome. The piperine derivative of the present invention can advantageously be used as a medical or functional food composition which suppresses the differentiation of adipocyte precursor cells and reduces the amount of triglycerides accumulated in cells and so ultimately exhibits an action in preventing or treating a metabolic disorder selected from the group consisting of obesity, diabetes, dyslipidaemia, fatty liver and insulin resistance syndrome.
(FR)La présente invention concerne un nouveau dérivé de pipérine. La présente invention concerne une composition pharmaceutique ou une composition d'aliment nutraceutique qui comprend un dérivé de pipérine comme principe actif, et qui permet de prévenir ou traiter un trouble métabolique choisi dans le groupe comprenant l'obésité, le diabète, la dyslipidémie, la stéatose hépatique et le syndrome de résistance à l'insuline. Le dérivé de pipérine selon la présente invention peut être avantageusement utilisé comme composition médicale ou composition d'aliment nutraceutique qui supprime la différenciation des cellules précurseurs des adipocytes et qui réduit la quantité de triglycérides accumulés dans les cellules et qui présente donc au final une action de prévention ou de traitement d'un trouble métabolique choisi dans le groupe comprenant l'obésité, le diabète, la dyslipidémie, la stéatose hépatique et le syndrome de résistance à l'insuline.
(KO)본 발명은 신규한 피페린 유도체에 관한 것이다. 본 발명은 피페린 유도체를 유효성분으로 포함하는 비만, 당뇨, 이상지방혈증, 지방간 및 인슐린 저항성 증후군으로 구성된 군으로부터 선택되는 대사질환의 예방 또는 치료용 약제학적 조성물 또는 기능성 식품 조성물을 제공한다. 본 발명의 피페린 유도체는 지방전구세포의 분화를 억제하고 세포내 중성지방의 축적량을 감소시킴으로써 궁극적으로 비만, 당뇨, 이상지방혈증, 지방간 및 인슐린 저항성 증후군으로 구성된 군으로부터 선택되는 대사질환의 예방 또는 치료 활성을 나타내는 의약 또는 기능성 식품 조성물로서 유용하게 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)