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1. (WO2013115201) NON-AQUEOUS LIQUID COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/115201    International Application No.:    PCT/JP2013/051951
Publication Date: 08.08.2013 International Filing Date: 30.01.2013
IPC:
A61K 47/16 (2006.01), A61K 9/10 (2006.01), A61K 47/10 (2006.01), A61K 47/32 (2006.01), A61P 27/02 (2006.01)
Applicants: SANTEN PHARMACEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Osaka-shi, Osaka 5338651 (JP)
Inventors: YAMADA, Kazuhito; (JP).
URTTI, Arto; (FI).
BURMESTER, Mechthild; (FI)
Agent: FUKAMI PATENT OFFICE, P.C.; Nakanoshima Central Tower, 2-7, Nakanoshima 2-chome, Kita-ku, Osaka-shi, Osaka 5300005 (JP)
Priority Data:
2012-018062 31.01.2012 JP
Title (EN) NON-AQUEOUS LIQUID COMPOSITION
(FR) COMPOSITION LIQUIDE NON AQUEUSE
(JA) 非水性液体組成物
Abstract: front page image
(EN)A drug-dissolved non-aqueous liquid composition comprising a drug, dioleylphosphatidylcholine, tocopherol and an organic solvent, wherein the ratio of the blend concentration of dioleylphosphatidylcholine to that of tocopherol falls within the range from 75/25 to 25/75, the blend concentration of dioleylphosphatidylcholine falls within the range from 15 to 85% (w/w) and the blend concentration of tocopherol falls within the range from 15 to 85% (w/w). The phase of the non-aqueous liquid composition can be changed into a non-lamellar liquid crystal upon the contact with water, a phosphate buffer, a body fluid, a tear fluid or a vitreous fluid.
(FR)Cette invention concerne une composition liquide non aqueuse contenant un médicament dissous, ladite composition contenant un médicament, de la dioléylphosphatidylcholine, du tocophérol et un solvant organique, le rapport de concentration en dioléylphosphatidylcholine sur celle en tocophérol étant compris entre 75/25 et 25/75, la concentration en dioléylphosphatidylcholine étant comprise dans la plage allant de 15 à 85 % (p/p) et la concentration en tocophérol étant comprise dans la plage allant de 15 à 85 % (p/p). La phase de la composition liquide non aqueuse peut être transformée en cristal liquide non lamellaire après contact avec de l'eau, un tampon phosphate, un liquide organique, un liquide lacrymal ou un liquide vitreux.
(JA) 薬物、ジオレイルフォスファチジルコリン、トコフェロールおよび有機溶媒を含有する薬物溶解型の非水性液体組成物であって、ジオレイルフォスファチジルコリンとトコフェロールの配合濃度比が75/25~25/75の範囲にあり、ジオレイルフォスファチジルコリンの配合濃度が15~85%(w/w)の範囲内であり、トコフェロールの配合濃度が15~85%(w/w)の範囲内であり、水、リン酸緩衝液、体液、涙液または硝子体液に接触することにより非ラメラ液晶に相変化する、非水性液体組成物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)