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1. (WO2013114296) IRON CHELATORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/114296 International Application No.: PCT/IB2013/050789
Publication Date: 08.08.2013 International Filing Date: 30.01.2013
IPC:
A61K 31/496 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
Applicants:
VARINEL INC. [US/US]; 929 South High Street, Suite 159 West Chester, PA 19382, US
Inventors:
ZURAWSKI, Vincent R. Jr; US
NITZ, Theodore, J.; US
Priority Data:
PCT/US2012/02333031.01.2012US
Title (EN) IRON CHELATORS AND USES THEREOF
(FR) CHÉLATEURS DE FER ET UTILISATIONS DE CEUX-CI
Abstract:
(EN) 8-Hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxy methyl, 8-phosphates, (phosphoryloxy)methyl, and 8-carbamates derivatives thereof substituted at the 5-position are described as useful for iron chelation and neuroprotective therapies. The compounds of Formula I are multifunctional compounds useful as iron chelators, as neuroprotective in the treatment of neurodegenerative diseases and disorders and as antibacterial.
(FR) La présente invention concerne des dérivés de 8-hydroxy-quinoléine et des dérivés 8-éthers, 8-esters, 8-carbonates, 8-acyloxyméthyle, 8-phosphates, 8(phosphoryloxy)méthyle, et 8-carbamates de ceux-ci substitués à la position 5, qui sont utiles pour la chélation du fer et des thérapies neuroprotectrices. Les composés de la formule I sont des composés multifonctionnels utiles en tant que chélateurs de fer, en tant que neuroprotecteurs dans le traitement des troubles et des maladies neurodégénératifs et en tant qu'antibactérien.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)