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1. (WO2013114296) IRON CHELATORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/114296    International Application No.:    PCT/IB2013/050789
Publication Date: 08.08.2013 International Filing Date: 30.01.2013
IPC:
A61K 31/496 (2006.01)
Applicants: VARINEL INC. [US/US]; 929 South High Street, Suite 159 West Chester, PA 19382 (US)
Inventors: ZURAWSKI, Vincent R. Jr; (US).
NITZ, Theodore, J.; (US)
Priority Data:
PCT/US2012/023330 31.01.2012 US
Title (EN) IRON CHELATORS AND USES THEREOF
(FR) CHÉLATEURS DE FER ET UTILISATIONS DE CEUX-CI
Abstract: front page image
(EN)8-Hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxy methyl, 8-phosphates, (phosphoryloxy)methyl, and 8-carbamates derivatives thereof substituted at the 5-position are described as useful for iron chelation and neuroprotective therapies. The compounds of Formula I are multifunctional compounds useful as iron chelators, as neuroprotective in the treatment of neurodegenerative diseases and disorders and as antibacterial.
(FR)La présente invention concerne des dérivés de 8-hydroxy-quinoléine et des dérivés 8-éthers, 8-esters, 8-carbonates, 8-acyloxyméthyle, 8-phosphates, 8(phosphoryloxy)méthyle, et 8-carbamates de ceux-ci substitués à la position 5, qui sont utiles pour la chélation du fer et des thérapies neuroprotectrices. Les composés de la formule I sont des composés multifonctionnels utiles en tant que chélateurs de fer, en tant que neuroprotecteurs dans le traitement des troubles et des maladies neurodégénératifs et en tant qu'antibactérien.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)