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1. (WO2013114232) PROCESS FOR PREPARATION OF CRYSTALLINE FORM L OF ILAPRAZOLE

Pub. No.:    WO/2013/114232    International Application No.:    PCT/IB2013/050327
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Tue Jan 15 00:59:59 CET 2013
IPC: C07D 401/14
A61K 31/4439
A61P 1/00
Applicants: LUPIN LIMITED
Inventors: BHATT, Nikhil, Shashikant
SHARMA, Madan, Kumar
RAKSHE, Priya, Deepak
SHAH, Chinal, Indravadan
KANTRODIYA, Suresh, Nagjibhai
PATEL, Sachin, Jasvant
PARMAR, Pradhuman, Amrutsinh
PATEL, Pravin, Shamjibhai
Title: PROCESS FOR PREPARATION OF CRYSTALLINE FORM L OF ILAPRAZOLE
Abstract:
The present invention relates to the process for preparation of crystalline form L of ilaprazole comprising steps of: i) heating the mixture of ilaprazole in aliphatic ketone containing tertiary organic amine, ii) cooling the mixture, iii) optionally seeding with form L and iv) isolating solid. The present invention further relates to the novel crystalline form L of ilaprazole characterized by a powder X-ray diffraction pattern having peaks at 6.60, 8.24 and 16.05 ± 0.2 degree 28 and an infra-red spectrum having peaks at 1417 and 1434 ± 5 cm-1.