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1. (WO2013114173) A NOVEL PROCESS FOR THE PREPARATION OF SITAGLIPTIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/114173    International Application No.:    PCT/IB2013/000099
Publication Date: 08.08.2013 International Filing Date: 28.01.2013
IPC:
C07D 487/04 (2006.01), C07C 227/16 (2006.01)
Applicants: SMILAX LABORATORIES LIMITED [IN/IN]; Plot No. 12/A, Phase-III, I.D.A. Jeedimetla Hyderabad 500 055 (IN).
MALLELA, Sambhu, Prasad, Sarma [IN/IN]; (IN) (US only).
HAVALE, Shrikant, Hanumantappa [IN/IN]; (IN) (US only).
BODDEPALLI, Nagabhushana, Rao [IN/IN]; (IN) (US only).
GUNJI, Nagarjuna [IN/IN]; (IN) (US only).
MOKKAPATI, Bhavani, Sankar [IN/IN]; (IN) (US only)
Inventors: MALLELA, Sambhu, Prasad, Sarma; (IN).
HAVALE, Shrikant, Hanumantappa; (IN).
BODDEPALLI, Nagabhushana, Rao; (IN).
GUNJI, Nagarjuna; (IN).
MOKKAPATI, Bhavani, Sankar; (IN)
Agent: K. NALINI MOHAN; Smilax Laboratories Limited Plot No. 12/A, Phase-III, I.D.A. Jeedimetla Hyderabad 500 055 (IN)
Priority Data:
338/CHE/2012 30.01.2012 IN
Title (EN) A NOVEL PROCESS FOR THE PREPARATION OF SITAGLIPTIN
(FR) NOUVEAU PROCÉDÉ DE PRÉPARATION DE SITAGLIPTINE
Abstract: front page image
(EN)The present invention is directed to a process for the preparation of enantiomerically enriched β-amino acid derivatives which are important chiral building blocks and intermediates in pharmaceuticals. More specifically, the invention pertains to a novel process for practically convenient and economically producing enantiomerically enriched β-amino acid derivatives which are useful for the synthesis of amide inhibitors of dipeptidyl peptidase IV like Sitagliptin, which have been used to treat type 2 diabetes.
(FR)La présente invention concerne un procédé de préparation de dérivés de β-aminoacides enrichis énantiomériquement qui sont des blocs de construction et des intermédiaires chiraux importants dans des produits pharmaceutiques. De manière plus spécifique, l'invention concerne un nouveau procédé de production pratique et économique de dérivés de β-aminoacides enrichis énantiomériquement, utiles pour la synthèse d'inhibiteurs de type amide de la dipeptidyle peptidase IV, analogues à la sitagliptine, qui ont été utilisés pour traiter le diabète de type 2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)