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1. (WO2013114165) PROCESS OF OBTAINING GLYCOPROTEIN COMPOSITION WITH INCREASED AFUCOSYLATION CONTENT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2013/114165 International Application No.: PCT/IB2012/057091
Publication Date: 08.08.2013 International Filing Date: 08.12.2012
IPC:
C07K 14/435 (2006.01) ,C12N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants: DR REDDY'S LABORATORIES LIMITED[IN/IN]; Biologics Development Center Survey No. 47, Bachupalli Qutubullapur RR District 500090, IN
Inventors: MAKKAPATI, Satakarni; IN
NIKAM, Vaibhav S; IN
SUBRAHMANYAM, Satyam; IN
Agent: SANTHANAM, Kausalya; 128/129 Royal Enclave Phase I Jakkur Post Srirampura Bangalore 560064, IN
Priority Data:
332/CHE/201230.01.2012IN
Title (EN) PROCESS OF OBTAINING GLYCOPROTEIN COMPOSITION WITH INCREASED AFUCOSYLATION CONTENT
(FR) PROCÉDÉ D'OBTENTION D'UNE COMPOSITION GLYCOPROTÉIQUE AYANT UNE TENEUR ACCRUE EN AFUCOSYLATION
Abstract:
(EN) The invention describes a cell culture process for obtaining a glycoprotein with the enhanced afucosylation content. The method involves culturing cells in a medium supplemented with galactose, at a specific osmolality, and harvesting on about 12th day or at about 50% viability to obtain glycoform composition with enhanced afucosylation.
(FR) L'invention concerne un procédé de culture de cellules pour obtenir une glycoprotéine ayant la teneur accrue en afucosylation. Le procédé imet en jeu la mise en culture des cellules dans un milieu enrichi en galactose, à une osmolalité spécifique et la récolte environ au 12ème jour ou à environ 50% de viabilité pour obtenir une composition de glycoforme ayant une afucosylation accrue.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)