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1. (WO2013113921) METHOD FOR OBTAINING INTEGRATED GENOMIC, TRANSCRIPTOMIC, PROTEOMIC AND/OR METABOLOMIC INFORMATION FROM A SINGLE UNIQUE BIOLOGICAL SAMPLE

Pub. No.:    WO/2013/113921    International Application No.:    PCT/EP2013/052134
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Tue Feb 05 00:59:59 CET 2013
IPC: G01N 33/68
C12N 15/10
Applicants: UNIVERSITÉ DU LUXEMBOURG
Inventors: WILMES, Paul
VLASSIS, Nikolaos
Title: METHOD FOR OBTAINING INTEGRATED GENOMIC, TRANSCRIPTOMIC, PROTEOMIC AND/OR METABOLOMIC INFORMATION FROM A SINGLE UNIQUE BIOLOGICAL SAMPLE
Abstract:
The invention provides a method for the generation of integrated genomic, transcriptomic, proteomic and/or metabolomic information from single unique biological samples. It includes the separation and purification of biomolecular components including polar and non-polar metabolites, genomic DNA, RNA and proteins from said samples. The invention allows the identification of associations between different biomolecules and genetic variants in heterogeneous cell populations. It further allows the establishment and quantification of cell population profiles in heterogeneous cell populations and/or in populations where the genomic context is unknown.