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1. WO2013113861 - MULTICOLOUR EXCITATION MODULE FOR A MULTIPHOTON IMAGING SYSTEM, AND ASSOCIATED METHOD AND SYSTEM

Publication Number WO/2013/113861
Publication Date 08.08.2013
International Application No. PCT/EP2013/052002
International Filing Date 01.02.2013
IPC
G01N 21/64 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G02B 21/00 2006.1
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
CPC
G01N 2021/6419
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6417Spectrofluorimetric devices
6419Excitation at two or more wavelengths
G01N 21/3151
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
314with comparison of measurements at specific and non-specific wavelengths
3151using two sources of radiation of different wavelengths
G01N 21/6402
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6402Atomic fluorescence; Laser induced fluorescence
G01N 21/6456
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
G01N 21/6458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
6458Fluorescence microscopy
G01N 2201/06113
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
06Illumination; Optics
061Sources
06113Coherent sources; lasers
Applicants
  • ECOLE POLYTECHNIQUE [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR]
Inventors
  • MAHOU, Pierre
  • BEAUREPAIRE, Emmanuel, Jean-Marc
  • DEBARRE, Delphine
  • SUPATTO, Willy
  • MARTIN, Jean Louis
Agents
  • PONTET ALLANO & ASSOCIES
Priority Data
125099002.02.2012FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) MULTICOLOUR EXCITATION MODULE FOR A MULTIPHOTON IMAGING SYSTEM, AND ASSOCIATED METHOD AND SYSTEM
(FR) MODULE D'EXCITATION MULTI-COULEURS POUR UN SYSTEME D'IMAGERIE MULTI-PHOTONIQUE, SYSTEME ET PROCEDE ASSOCIES
Abstract
(EN)
The present invention concerns a multicolour excitation module 1 for a multiphoton imaging system 100. Such a module is used for imaging a sample 7 comprising at least three chromophores. The module 1 comprises: a first femtosecond laser source 2, emitting a first excitation beam 20; a second femtosecond laser source 3 emitting a second excitation beam 30. The first excitation beam 20 comprises a so-called "pumping" portion, said pumping portion acting as a pump beam to synchronously excite the second laser source 3, and a so-called "excitation" portion. An optical delay line 4 is arranged to spatially and temporally superpose the second excitation beam 30 and the excitation portion of the first excitation beam, so as to excite at least a third of the chromophores by multiphoton absorption, said absorbed photons coming from the first and second excitation beams 20, 30. The invention also concerns the complete multiphoton imaging system 100, and a method implemented in this module 1.
(FR)
La présente invention concerne un module 1 d'excitation multi-couleurs pour un système d'imagerie multi-photonique 100. Un tel module est utilisé pour imager un échantillon 7 comprenant au moins trois chromophores. Le module 1 comprend : une première source de laser femtoseconde 2, émettant un premier faisceau d'excitation 20; une deuxième source laser femtoseconde 3 émettant un deuxième faisceau d'excitation 30. Le premier faisceau d'excitation 20 comprend une partie dite « de pompage », cette partie de pompage servant de faisceau de pompe pour exciter de façon synchrone la deuxième source laser 3, et une partie dite « d'excitation ». Une ligne à retard optique 4 est agencée pour superposer spatialement et temporellement le deuxième faisceau d'excitation 30 et la partie d'excitation du premier faisceau d'excitation, de façon à exciter au moins un troisième des chromophores par absorption multi-photons, lesdits photons absorbés provenant des premier et deuxième faisceaux d'excitation 20,30. L'invention concerne également le système complet d'imagerie multi-photonique 100, ainsi qu'un procédé mis en oeuvre dans ce
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