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1. (WO2013113729) FERMENTATION PROCESS

Pub. No.:    WO/2013/113729    International Application No.:    PCT/EP2013/051743
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Thu Jan 31 00:59:59 CET 2013
IPC: A61K 39/00
Applicants: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventors: DEHOTTAY, Philippe Marc Helene
GOFFIN, Philippe
Title: FERMENTATION PROCESS
Abstract:
The present invention relates to a process for fermenting Bordetella comprising a) providing a sample of bacteria of a Bordetella species; b) incubating the sample of bacteria of a Bordetella species in a first environment under at least one bvg (Bordetella virulence genes) modulating condition for at least 5 generations, thereby producing a mature culture; c) incubating the mature culture in a second environment in the absence of the at least one bvg modulating condition; wherein step c) occurs after step b).