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1. (WO2013113707) SYSTEM FOR DETECTING GENES IN TISSUE SAMPLES

Pub. No.:    WO/2013/113707    International Application No.:    PCT/EP2013/051705
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Wed Jan 30 00:59:59 CET 2013
IPC: G06K 9/00
G06T 7/00
G06T 7/40
C12Q 1/68
Applicants: VENTANA MEDICAL SYSTEMS, INC.
F. HOFFMANN-LA ROCHE AG
BAMFORD, Pascal
CHUKKA, Srinivas
MARTIN, Jim F.
SARKAR, Anindya
SERTEL, Olcay
SUZUE, Ellen
VARANGAONKAR, Harshal
Inventors: BAMFORD, Pascal
CHUKKA, Srinivas
MARTIN, Jim F.
SARKAR, Anindya
SERTEL, Olcay
SUZUE, Ellen
VARANGAONKAR, Harshal
Title: SYSTEM FOR DETECTING GENES IN TISSUE SAMPLES
Abstract:
A computer-based specimen analyzer (10) is configured to detect a level of expression of genes in a cell sample by detecting dots that represent differently stained genes and chromosomes in a cell. The color of the stained genes and the chromosomes is enhanced and filtered to produce a dot mask that defines areas in the image that are genes, chromosomes, or non-genetic material. Metrics are determined for the dots and/or pixels in the image of the cell in areas corresponding to the dots. The metrics are fed to a classifier that separates genes from chromosomes. The results of the classifier are counted to estimate the expression level of genes in the tissue samples.