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1. (WO2013113279) DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE

Pub. No.:    WO/2013/113279    International Application No.:    PCT/CN2013/071155
Publication Date: Fri Aug 09 01:59:59 CEST 2013 International Filing Date: Thu Jan 31 00:59:59 CET 2013
IPC: C07D 407/02
C09K 3/00
B41M 5/327
B41M 5/20
Applicants: THE UNIVERSITY OF HONG KONG
Inventors: YANG, Dan
PENG, Tao
SHEN, Jiangang
CHEN, Xingmiao
Title: DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE
Abstract:
Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high- throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.